Anemia Studies

1.  Testosterone Induces Erythrocytosis via Increased Erythropoietin and Suppressed Hepcidin: Evidence for a New Erythropoietin/Hemoglobin Set Point

Eric Bachman, 1 Thomas G. Travison, 2 Shehzad Basaria, 1 Maithili N. Davda, 2Wen Guo, 2 Michelle Li, 2 John Connor Westfall, 1 Harold Bae, 1 Victor Gordeuk, 2 and Shalender Bhasin 3

  1. Testosterone alters iron metabolism and stimulates red blood cell production independently of dihydrotestosterone

Luke A. Beggs,1,4 Joshua F. Yarrow,1,4 Christine F. Conover,1 John R. Meuleman,2Darren T. Beck,7 Matthew Morrow,3 Baiming Zou,5 Jonathan J. Shuster,6 and Stephen E. Borst2,4

  1. Depressed response of the erythropoietin-responsive splenic cell population to erythropoietin in acutely protein restricted mice. In Vivo. 1995 Jan-Feb;9(1):71-3.
  1. Jelkmann W, Kurtz A, Bauer C., Effects of fasting on the hypoxia-induced erythropoietin production in rats. Pflugers Arch. 1983 Feb;396(2):174-5.
  1. [14]Foley JE, Gross DM, Nelson PK, Fisher JW. The effects of arachidonic acid on erythropoietin production in exhypoxic polycythemic mice and the isolated perfused canine kidney. J Pharmacol Exp Ther. 1978 Nov;207(2):402-9.

More information: Xiaofei Gao et al. Thyroid hormone receptor beta and NCOA4 regulate terminal erythrocyte differentiation, Proceedings of the National Academy of Sciences (2017). DOI: 10.1073/pnas.1711058114

Journal information: Proceedings of the National Academy of Sciences 

  1. Kathleen M. Schieffer et al., JAMA Otolaryngology - Head & Neck Surgery, doi: 10.1001/jamaoto.2016.3631, published online 29 December 2016. 
    Association of iron deficiency anemia with hearing loss in US adults
  2. Jeffery L. Miller, Cold Spring Harbor Perspectives in Medicine, doi: 10.1101/cshperspect.a011866, published online July 2013. 
    Iron deficiency anemia: A common and curable disease
  3. 10. Sudden sensorineural hearing loss associated with iron-deficiency anemia: a population-based study, SD Chung et al., JAMA Otolaryngology - Head & Neck Surgery, doi: 10.1001/jamaoto.2014.75, published online May 2014, .
  4. Phyo Myint et al., Journal of the American Heart Association, doi: 10.1161/JAHA.115.003019, published online 17 August 2016. 
    Impact of hemoglobin levels and anemia on mortality in acute stroke: analysis of UK regional registry data, systematic review, and meta‐analysis
  5. American Heart Association , accessed 17 August 2016 via EurekAlert.
    news release